Hangzhou Excelente Chemicals Co., Ltd.  

Product Name: Adapalene, Adapalen, Pharm Grade Good Quality Model NO.: 99% Purity: >99% State: Solid Suitable for: Elderly, Children, Adult Certification: ISO 9001 Customized: Non-Customized Powder: Yes Trademark: Excelente Transport Package: 100g/500g/1kg/2kg/5kg Aluminum Foil/Tin Specification: 99% Origin: Zhejiang HS Code: 2942000000 Product Description Product descriptionAdapalene is a new naphthoic acid derivatives developed by the French company Galdeama Laboratories. It was first marketed in France in June 1996 under the trade name "Differin" and is mainly used to improve inflammatory skin lesions and regulate hair follicles , Sebaceous gland epithelial cell differentiation and acne treatment.Adapalene is a retinoid that has been shown to have anti-inflammatory properties in in vivo and in vitro inflammatory models, is chemically stable, does not decompose readily in air and light. The mechanism of action is the same as that of retinoic acid and binds to specific retinoid receptors, with the difference that adapalene does not bind to protein-bound cytoplasmic receptors. Dermatological testing in animal models established in mice has demonstrated that adapalene can treat acne and also has an effect on acne vulgaris and the process of differentiation. The mechanism of action is to reduce the formation of small acne by normal differentiation of hair follicle cells. In standard in vitro and in vivo anti-inflammatory assays. Adaptant is superior to retinoid acid in that it inhibits the chemotactic response of human polymorphonuclear leukocytes and inhibits the metabolism of polymorphic nucleocapsids by inhibiting the conversion of arachidonic acid to adipogenic mediators via lipid oxidation , Thereby alleviating the inflammatory response mediated by cellular responses. Suitable for the treatment of acne vulgaris with acne vulgaris that acne, pimples and pustules are the main manifestations. It can also be used to treat acne on the face, chest and back.ApplicationIt stimulates cell division in the skin and reduces the production of keratin. It aids skin peeling and prevents the formation of acne lesions (comedones). The action of adapalene combats the changes that take place in acne.Adapalene is used in the treatment of mild to moderate acne. It is best suited to dry and fair skin.Adapalene Powder is a white to off-white powder, which is soluble in tetrahydrofuran, very slightly soluble in ethanol, and practically insoluble in water. Adapalene has actions similar to vitamin A (retinol).Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. It is effective against acne conditions where comedones are predominant.Package100g/200g/500g/1kg/2kg/5kg aluminum foil/tinSpecificationAnalysis ItemIndexesCharacteristicsWhiteor almost white crystalline powderIdentificationIRSolubility Practically insoluble in water and ethanol, sparingly soluble in tetrahydrofuran.Appearance of solutionSolution must be clear and color NMT BY6 of EPHeavy metals≤20ppmLoss on drying≤0.5%Sulfated ash≤0.1%Related substancesImpurity A:≤0.3%ImpurityD: ≤0.2%Impurity C:≤0.15%Unknown impurity:≤0.1%Total impurity: ≤0.5%Residue solventsTetrahydrofuran:≤720ppmAcetic acid:≤5000ppmMethanol:≤3000ppmDichloromethane:≤600ppmN,N-dimethyl formamide:≤880ppmAssay(on dried basis)98.0%-102.0%